Geschlechtsspezifische Unterschiede urologischer Tumore

Zusammenfassung

Geschlechtsunterschiede in der Medizin spielen mittlerweile eine nicht mehr wegzudenkende Rolle, sowohl in Diagnostik als auch Therapie. Risikofaktoren und Mortalität variieren je nach Geschlecht, Krankheiten äußern sich unterschiedlich. In der Diagnostik müssen je nach Geschlecht unterschiedliche Aspekte in Betracht gezogen werden. Bei Blasenkarzinomen zum Beispiel kommt es bei Frauen häufig zu Verzögerungen bei der Diagnose, weil Hämaturie oft benignen Erkrankungen wie Harnwegsinfekten zugeschrieben wird.
Bei Therapieentscheidungen sollte das Geschlecht ebenso eine Rolle spielen. Um ein Beispiel zu nennen, haben Immuncheckpoint-Inhibitoren bei Nierenzellkarzinomen bei Männern ein besseres Ansprechen als bei Frauen. Auch die Outcomes nach onkologischer Therapie bei urologischen Tumoren variieren nach Geschlecht.

Abstract

Gender differences in medicine are playing an increasingly important role in diagnostic testing as well as therapy choices. Risk factors and mortality vary depending on gender. Diseases often manifest differently depending on gender. In diagnostic testing, gender-specific aspects need to be taken into consideration. For instance, bladder cancer diagnosis is often delayed in women compared to men as haematuria is frequently attributed to benign conditions like urinary tract infections. In therapy, decisive gender disparities should also be considered. To state an example, immune-checkpoint inhibitors have shown better response in men than in women when treating renal cell carcinoma. Furthermore, outcomes after treatment for urological tumours differ depending on gender.

Schlüsselwörter

Geschlechtsunterschiede - Urologische Tumore - Urothelkarzinom

Keywords

Gender Differences - Urological Tumors - Urothelial Cancer

Publication History

Received: 05 November 2024

Accepted after revision: 04 March 2025

Article published online:
03 April 2025

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